Synthesis and Biodistribution of N- [(2RS, 3RS)-1-Benzyl-2-Methyl-3-Pyrrolidinyl]-5-Chloro-2-Methoxy-4-[11C]Methylaminobenzamide, [11C]YM-09151-2: A New in Vivo Ligand for Dopamine D2 Receptors

開始ページ、終了ページ: 冊子体のページ付

Production and optical properties of liquid scintillator for the JSNS2^{2} experiment

The JSNS$^{2}$ (J-PARC Sterile Neutrino Search at J-PARC Spallation Neutron Source) experiment will search for neutrino oscillations over a 24 m short baseline at J-PARC. The JSNS$^{2}$ inner detector will be filled with 17 tons of gadolinium-loaded liquid scintillator (LS) with an additional 31 tons of unloaded LS in the intermediate $\gamma$-catcher and outer veto volumes. JSNS$^{2}$ has chosen Linear Alkyl Benzene (LAB) as an organic solvent because of its chemical properties. The unloaded LS was produced at a refurbished facility, originally used for scintillator production by the RENO experiment. JSNS$^{2}$ plans to use ISO tanks for the storage and transportation of the LS. In this paper, we describe the LS production, and present measurements of its optical properties and long term stability. Our measurements show that storing the LS in ISO tanks does not result in degradation of its optical properties.Comment: 7 pages, 4 figures

Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier

Functional and structural age-associated changes in the blood-brain barrier (BBB) may affect the neurovascular unit and contribute to the onset and progression of age-associated neurodegenerative pathologies, including Alzheimer’s disease. The current study interrogated the RNA profile of the BBB in an ageing human autopsy brain cohort and an ageing mouse model using combined laser capture microdissection and expression profiling. Only 12 overlapping genes were altered in the same direction in the BBB of both ageing human and mouse cohorts. These included genes with roles in regulating vascular tone, tight junction protein expression and cell adhesion, all processes prone to dysregulation with advancing age. Integrated mRNA and miRNA network and pathway enrichment analysis of the datasets identified 15 overlapping miRNAs that showed altered expression. In addition to targeting genes related to DNA binding and/or autophagy, many of the miRNAs identified play a role in age-relevant processes, including BBB dysfunction and regulating the neuroinflammatory response. Future studies have the potential to develop targeted therapeutic approaches against these candidates to prevent vascular dysfunction in the ageing brain

Synthesis of C-11 Tamoxifen and its Biodistributtion

開始ページ、終了ページ: 冊子体のページ付

Biostratigraphy, paleomagnetism and sedimentology of Late Cenozoic sediments in northwestern Hokkaido, Japan

Four Neogene sedimentary basins in northwestern Hokkaido (latitudes 44°-45° N.), the northernmost island of Japan, were studied to establish a combined microfossil-paleomagnetic sedimentologic stratigraphy. The measured section near Atsuta encompasses a shoaling depositional sequence from upper bathyal depths in the lower part to stagnant, nearshore conditions near the top of the sequence. Magnetostratigraphic evidence and age-diagnostic diatoms indicate the section to be Late Miocene age covering the interval from early Epoch 5 through Epoch 6, and possibly to late Epoch 7. The second measured section located north of Shosanbetsu exposes sediments derived from a volcano-clastic source and deposited on a continental slope with oversteepened slopes. Rich diatom floras from the sequence are assignable to the Denticula seminae var. fossilis-D. kamtschatica and D. kamtschatica Zones. A magnetic signature containing one reversal was observed in the upper part of the section, although the data seem to indicate the lower section to be dominantly normally magnetized. In the northwest Pacific deep-sea sequences, the zonal boundary of these two diatom zones lies between the Nunivak ( = "b") and "c" Events of the Gilbert Epoch, thus the distinct magnetic reversal observed in the upper part of the sequence is correlated with the top of the Nunivak Event. Neogene strata developed near Wakkanai City, the northwestern tip of Hokkaido, appear to have been deposited during a time interval of predominantly reversed geomagnetic polarity. Diatom floras suggest a correlation of these strata with the Denticula kamtschatica Zone which in turn corresponds, in the northwest Pacific deep-sea sequences, to the lower Gilbert Series below a horizon midway between the Nunivak and "c" Events. Diatom rich sediments of the Shimo-Ebekorobetsu area belong to the Yuchi Formation and comprise two assemblages assignable to the D. kamtschatica Zone and the superjacent Denticula seminae var.fossilis-D. kamtschatica Zone. From northern Honshu through Hokkaido to Sakhalin, in the western Pacific coastal region, beds containing the large pecten Fortipecten takahashii (YOKOYAMA) constitute a marker horizon useful for inter-regional correlation. In its southern range of distribution, F. takahashii is a diagnostic species in the lower part of the Tatsunokuchi Formation from which diatom floras assignable to the D. seminae var. fossilis-D. kamtschatica Zone are described. The F. takahashii bed occurs in the Shosanbetsu section, lying within the same diatom zone as the Tastunokuchi Formation and is in a reversely magnetized interval above the Nunivak Event (3.9 m.y. B.P.). The Neogene marine sediments of northwestern Hokkaido were deposited in the back-arc basin and reveal evidence of active arc magmatism at the time of deposition. In this tectonically active back-arc region, sediment-collecting basins shifted from area to area, accumulating sediments only for a relatively short period of time when spurts of active subsidence occurred in a given sedimentary basin

A Measurement of the Branching Fraction for the Inclusive B --> X(s) gamma Decays with the Belle Detector

We have measured the branching fraction of the inclusive radiative B meson decay B --> X(s) gamma to be Br(B->X(s)gamma)=(3.36 +/- 0.53(stat) +/- 0.42(sys) +0.50-0.54(th)) x 10^{-4}. The result is based on a sample of 6.07 x 10^6 BBbar events collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric e^+e^- storage ring.Comment: 14 pages, 6 Postsript figures, uses elsart.cl

Measurement of B0d - B0d-bar mixing rate from the time evolution of dilepton events at the Upsilon(4S)

We report a determination of the B0d - B0d-bar mixing parameter Delta-m_d based on the time evolution of dilepton yields in Upsilon(4S) decays. The measurement is based on a 5.9 /fb data sample collected by the Belle detector at KEKB. The proper-time difference distributions for same-sign and opposite-sign dilepton events are simultaneously fitted to an expression containing Delta-m_d as a free parameter. Using both muons and electrons, we obtain Delta-m_d = 0.463 +- 0.008(stat.) +- 0.016(sys.) ps^{-1} This is the first determination of Delta-m_d from time evolution measurements at the Upsilon(4S). We also place limits on possible CPT violations.Comment: 12 pages, 2 figure

Measurement of the CP Violation Parameter sin(2phi_1) in B^0_d Meson Decays

We present a measurement of the Standard Model CP violation parameter sin(2phi_1) based on a 10.5 fb^{-1} data sample collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric e+e- collider. One neutral B meson is reconstructed in the J/psi K_S, psi(2S) K_S, chi_{c1} K_S, eta_c K_S, J/psi K_L or J/psi pi^0 CP-eigenstate decay channel and the flavor of the accompanying B meson is identified from its charged particle decay products. From the asymmetry in the distribution of the time interval between the two B-meson decay points, we determine sin(2phi_1) = 0.58 +0.32-0.34 (stat) +0.09-0.10 (syst).Comment: LaTex, 13 pages, 3 figures, submitted to P.R.

The Met Office Unified Model Global Atmosphere 7.0/7.1 and JULES Global Land 7.0 configurations

We describe Global Atmosphere 7.0 and GlobalLand 7.0 (GA7.0/GL7.0), the latest science configurations of the Met Office Unified Model (UM) and the Joint UK Land Environment Simulator (JULES) land surface model developed for use across weather and climate timescales. GA7.0 and GL7.0 include incremental developments and targeted improvements that, between them, address four critical errors identified in previous configurations: excessive precipitation biases over India, warm and moist biases in the tropical tropopause layer (TTL), a source of energy non-conservation in the advection scheme and excessive surface radiation biases over the Southern Ocean. They also include two new parametrisations, namely the UK Chemistry and Aerosol(UKCA) GLOMAP-mode (Global Model of Aerosol Processes) aerosol scheme and the JULES multi-layer snow scheme, which improve the fidelity of the simulation and were required for inclusion in the Global Atmosphere/Global Land configurations ahead of the 6th Coupled Model Inter-comparison Project (CMIP6).In addition, we describe the GA7.1 branch configuration, which reduces an overly negative anthropogenic aerosol effective radiative forcing (ERF) in GA7.0 whilst maintaining the quality of simulations of the present-day climate. GA7.1/GL7.0 will form the physical atmosphere/land component in the HadGEM3–GC3.1 and UKESM1 climate model submissions to the CMIP6

Identification of QTL underlying vitamin E contents in soybean seed among multiple environments

Vitamin E (VE) in soybean seed has value for foods, medicines, cosmetics, and animal husbandry. Selection for higher VE contents in seeds along with agronomic traits was an important goal for many soybean breeders. In order to map the loci controlling the VE content, F5-derived F6 recombinant inbred lines (RILs) were advanced through single-seed-descent (SSD) to generate a population including 144 RILs. The population was derived from a cross between ‘OAC Bayfield’, a soybean cultivar with high VE content, and ‘Hefeng 25’, a soybean cultivar with low VE content. A total of 107 polymorphic simple sequence repeat markers were used to construct a genetic linkage map. Seed VE contents were analyzed by high performance liquid chromatography for multiple years and locations (Harbin in 2007 and 2008, Hulan in 2008 and Suihua in 2008). Four QTL associated with α-Toc (on four linkage groups, LGs), eight QTL associated with γ-Toc (on eight LGs), four QTL associated with δ-Toc (on four LGs) and five QTL associated with total VE (on four LGs) were identified. A major QTL was detected by marker Satt376 on linkage group C2 and associated with α-Toc (0.0012 > P > 0.0001, 5.0% < R2 < 17.0%, 25.1 < α-Toc < 30.1 μg g−1), total VE (P < 0.0001, 7.0% < R2 < 10.0%, 118.2 < total VE < 478.3 μg g−1). A second QTL detected by marker Satt286 on LG C2 was associated with γ-Toc (0.0003 > P > 0.0001, 6.0% < R2 < 13.0%, 141.5 < γ-Toc < 342.4 μg g−1) and total VE (P < 0.0001, 2.0% < R2 < 9.0%, 353.9 < total VE < 404.0 μg g−1). Another major QTL was detected by marker Satt266 on LG D1b that was associated with α-Toc (0.0002 > P > 0.0001, 4.0% < R2 < 6.0%, 27.7 < α-Toc < 43.7 μg g−1) and γ-Toc (0.0032 > P > 0.0001, 3.0% < R2 < 10.0%, 69.7 < γ-Toc < 345.7 μg g−1). Since beneficial alleles were all from ‘OAC Bayfield’, it was concluded that these three QTL would have great potential value for marker assisted selection for high VE content